This document provides recommendations and requirements on the major processes necessary to provide safety assurance for software in ANS systems, a recommended ANS Software lifecycle and its associated activities in support of achieving the objectives identified herein, a reference to other standards (focusing on ED-109/DO-278, ISO/IEC 12207, IEC 61508, CMMi and ED-12B/DO-178B) that relate to the identified objectives, an assessment of the referenced standards’ coverage of the recommended lifecycle and its associated activities for the development, operation and maintenance of ANS software, and a guidance towards satisfying ESARR6 and EC Regulation 482/2008.